| 1 | The Hill School | Pottstown, Pennsylvania | 20-1-0 | PAISAA Champions, MAPL Champions |
| 2 | Lower Dauphin High School | Hummelstown, Pennsylvania | 21-3-1 | PIAA AAA State Champions, District 2 AAA Champions |
| 3 | Mechanicsburg High School | Mechanicsburg, Pennsylvania | 21-4-1 | PIAA AA State Champions, District 3 AA Third Place |
| 4 | Palmyra Area High School | Palmyra, Pennsylvania | 21-3-2 | PIAA AA State Finalist, District 3 AA Champions |
| 5 | Wilson High School | West Lawn, Pennsylvania | 24-3-1 | District 3 AAA Finalist |
| 6 | Emmaus High School | Emmaus, Pennsylvania | 25-1-0 | PIAA AAA State Semifinalist, District XI AAA Champions |
| 7 | The Episcopal Academy | Newtown Square, Pennsylvania | 16-4-2 | PAISAA Finalist, Inter-AC Champions |
| 8 | Boiling Springs High School | Boiling Springs, Pennsylvania | 26-0-0 | PIAA A Champions, District 3 A Champions |
| 9 | Villa Maria Academy | Malvern, Pennsylvania | 18-7-0 | PIAA AA State Semifinalist, District I AA Champions |
| 10 | Hershey High School | Hershey, Pennsylvania | 17-4-1 | PIAA AA Quarterfinalist, District 3 AA Finalist |
| 11 | Gwynedd Mercy Academy High School | Gwynedd Valley, Pennsylvania | 18-5-1 | PIAA AA State Semifinalist, District I AA Finalist |
| 12 | Downingtown West High School | Downingtown, Pennsylvania | 20-4-0 | District I AAA Champions. PIAA AAA State Quarterfinalist |
| 13 | Conestoga High School | Berwyn, Pennsylvania | 22-3-0 | PIAA AAA State Semifinalist, District I AAA Finalist |
| 14 | Wyoming Area High School | Exeter, Pennsylvania | 20-3-0 | PIAA A Finalist, District 2 A Champions |
| 15 | Academy of Notre Dame de Namur | Villanova, Pennsylvania | 16-5-0 | PAISAA Semifinalist |
| 16 | Oley Valley High School | Oley, Pennsylvania | 23-3-1 | PIAA A State Semifinalist, District 3 A Finalist |
| 17 | Wyoming Seminary | Kingston, Pennsylvania | 16-5-1 | District 2 A Finalist |
| 18 | Manheim Township High School | Lancaster, Pennsylvania | 20-7-0 | District 3 AAA Third Place. PIAA AAA Quarterfinalist |
| 19 | Great Valley High School | Malvern, Pennsylvania | 19-4-0 | District I AAA Third Place. PIAA AAA State Quarterfinalist |
| 20 | Penn Manor High School | Millersville, Pennsylvania | 17-6-0 | District 3 AAA Fourth Place. PIAA AAA First Round |
| | | | |
| OC | Lake-Lehman High School | Lehman, Pennsylvania | 15-4-0 | District 2 A Semifinalist |
| OC | Methacton High School | Eagleville, Pennsylvania | 18-5-0 | District I AAA 5th Place. PIAA AAA First Round |
| OC | Pine-Richland High School | Gibsonia, Pennsylvania | 19-1-1 | PIAA AAA First Round, District 7 Champions |
2022 PENNSYLVANIA REGION HIGH SCHOOL
