| 1 | Walpole High School | Walpole, Massachusetts | 17-0-0 | 1 | 10/25 @Wellesley- 3-0 W, 10/29 vs Brookline- 4-0 W, 10/30 vs Braintree- 5-0 W | |
| 2 | Andover High School | Andover, Massachusetts | 16-0-1 | 2 | 10/25 @North Andover- 5-0 W | |
| 3 | Masconomet Regional High School | Boxford, Massachusetts | 16-0-1 | 3 | 10/27 @Swampscott- 5-1 W | |
| 4 | Phillips Academy Andover | Andover, Massachusetts | 12-0-1 | 4 | 10/27 vs BB&N- 1-0 W, 10/30 @Deerfield- 1-0 W | |
| 5 | Watertown High School | Watertown, Massachusetts | 18-0-0 | 5 | 10/25 vs Wilmington- 6-0 W, 10/29 vs Stoneham- 6-0 W | |
| 6 | Skowhegan Area High School | Skowhegan, Maine | 16-0-0 | 6 | 10/27 vs Camden Hills- 5-0 W, 10/30 vs Messalonskee- 4-1 W | |
| 7 | Franklin High School | Franklin, Massachusetts | 18-1-0 | 7 | 10/28 vs King Philip- 2-0 W, 10/29 vs Milford- 11-0 W | |
| 8 | Tabor Academy | Marion, Massachusetts | 10-3-0 | 8 | 10/30 @Groton- 1-0 W | |
| 9 | Cheverus High School | Portland, Maine | 17-0-0 | 9 | 10/27 vs Kennebunk- 5-1 W, 10/30 vs Falmouth- 7-0 W | |
| 10 | Exeter High School | Exeter, New Hampshire | 18-1-0 | 13 | 10/27 vs Winnacunnet- 5-0 W, 10/31 vs Windham- 2-1 W. NHIAA Division I State Champions | |
| 11 | Concord-Carlisle High School | Concord, Massachusetts | 13-1-1 | 14 | 10/28 @Lincoln-Sudbury- 3-0 W, 10/29 vs Acton Boxborough- 2-1 W | |
| 12 | Brooks School | North Andover, Massachusetts | 10-1-1 | 11 | 10/27 vs Lawrence- 7-1 W, 10/30 @Governor's Academy- 1-0 W | |
| 13 | Wellesley High School | Wellesley, Massachusetts | 13-2-1 | 10 | 10/25 vs Walpole- 0-3 L, 10/27 @NNatick- 3-1 W | |
| 14 | Winchester High School | Winchester, Massachusetts | 14-1-2 | 12 | 10/25 vs Woburn- 6-0 W, 10/27 @Lexington- 1-0 W | |
| 15 | Sandwich High School | East Sandwich, Massachusetts | 14-1-2 | 18 | 10/25 @Barnstable- 3-0 W, 10/29 vs Plymouth North- 3-0 W, 10/31 vs Middleborough- 4-0 W | |
| 16 | Middlesex School | Concord, Massachusetts | 10-3-1 | 15 | 10/27 @Rivers School- 3-4 L OT, 10/30 vs Thayer- 3-2 W OT | |
| 17 | Noble & Greenough School | Dedham, Massachusetts | 9-2-0 | 20 | 10/28 vs Governor's Academy- 2-1 W, 10/29 vs Lawrence Academy- 8-0 W | |
| 18 | Westwood High School | Westwood, Massachusetts | 11-1-1 | 19 | 10/25 @Holliston- 2-0 W | |
| 19 | Windham High School | Windham, New Hampshire | 15-3-1 | OC | 10/27 vs Bedford- 4-3 W, 10/31 vs Exeter- 1-2 L. NHIAA Division I State Runner-Up | |
| 20 | Scarborough High School | Scarborough, Maine | 16-1-0 | OC | 10/26 vs Noble- 2-0 W, 10/29 vs Biddeford- 2-1 W | |
| | | | | | |
| OC | Bedford High School | Bedford, New Hampshire | 16-2-0 | 16 | 10/27 vs Windham- 3-4 L. NHIAA Division I State Semifinalist | |
| OC | Bellows Falls Union High School | Westminster, Vermont | 15-0-0 | OC | 10/29 vs Colchester- 3-1 W | |
| OC | Deerfield Academy | Deerfield, Massachusetts | 7-4-2 | OC | 10/27 @Worcester Academy- 6-0 W, 10/30 vs Andover- 0-1 L | |
| OC | Falmouth High School | Falmouth, Massachusetts | 12-1-4 | OC | 10/29 @Hingham- 1-0 W, 10/31 vs Cohasset- 0-0 T | |
| OC | Nashoba Regional High School | Bolton, Massachusetts | 13-2-2 | OC | 10/25 vs Doherty- 2-0 W, 10/28 vs Shrewsbury- 1-1 T | |
| OC | South Burlington High School | South Burlington, Vermont | 14-0-1 | OC | 10/29 vs Mt. Mansfield- 4-1 W | |
| OC | The Rivers School | Weston, Massachusetts | 9-3-1 | NR | 10/27 vs Middlesex- 4-3 W, 10/30 @St. Mark's- 1-0 W | |
| OC | Wachusett Regional High School | Holden, Massachusetts | 11-1-4 | 17 | 10/25 vs Shrewsbury- 1-3 L | |
2021 NEW ENGLAND REGION HIGH SCHOOL
