| 1 | Emmaus High School | Emmaus, Pennsylvania | 22-0-0 | 1 | 10/28 vs Whitehall- 12-0 W | |
| 2 | Frank W. Cox High School | Virginia Beach, Virginia | 14-0-0 | 2 | 10/26 vs Salem- 10-0 W, 10/28 vs Tallwood- 13-0 W | |
| 3 | Episcopal Academy | Newtown Square, Pennsylvania | 16-1-0 | 3 | 10/27 vs Springside Chestnut Hill Academy- 9-2 W, 10/29 vs Penn Charter- 10-0 W | |
| 4 | The Hill School | Pottstown, Pennsylvania | 15-1-0 | 4 | 10/27 vs Germantown Academy- 7-1 W, 10/30 vs Mercersburg Academy- 6-0 W | |
| 5 | Lower Dauphin High School | Hummelstown, Pennsylvania | 18-0-1 | 5 | 10/30 vs Dallastown- 2-1 W | |
| 6 | Villa Maria Academy | Malvern, Pennsylvania | 16-2-1 | 6 | 10/26 vs Harriton- 13-0 W, 10/28 vs Pope John Paul II- 10-0 W | |
| 7 | Wyoming Seminary | Kingston, Pennsylvania | 16-2-0 | 7 | 10/28 vs Tunkhannock- 12-0 W | |
| 8 | Eastern Regional High School | Voorhees, New Jersey | 18-2-0 | 8 | 10/28 vs Jackson Memorial- 12-0 W | |
| 9 | Delmar High School | Delmar, Delaware | 14-0-0 | 9 | 10/25 @Woodbridge- 10-0 W, 10/28 vs Padua Academy- 10-0 W | |
| 10 | Palmyra Area High School | Palmyra, Pennsylvania | 16-1-1 | 10 | 10/27 vs West Perry- 3-1 W, 10/30 vs Hershey- 5-0 W | |
| 11 | Kinkaid School | Houston, Texas | 13-1-0 | 11 | 10/28 vs St. John's School- 4-3 W | |
| 12 | Norfolk Academy | Norfolk, Virginia | 15-2-0 | 12 | 10/27 vs Walsingham Academy- 8-0 W, 10/29 vs Collegiate School- 8-4 W | |
| 13 | Oak Knoll School | Summit, New Jersey | 17-2-0 | 13 | 10/27 @Kingsway- 3-2 W | |
| 14 | Conestoga High School | Berwyn, Pennsylvania | 19-1-0 | 14 | 10/27 vs Downingtown East- 4-0 W, 10/29 vs Kennett- 3-0 W | |
| 15 | West Essex Regional High School | Caldwell, New Jersey | 18-2-0 | 15 | 10/27 vs High Point- 8-0 W | |
| 16 | Camden Catholic High School | Cherry Hill, New Jersey | 18-2-0 | 16 | None | |
| 17 | Gwynedd Mercy Academy High School | Gwynedd Valley, Pennsylvania | 14-2-1 | 17 | 10/26 vs Strath Haven- 14-0 W, 10/28 vs WC East- 5-0 W | |
| 18 | Kingsway Regional High School | Woolwich Township, New Jersey | 17-2-0 | 18 | 10/27 vs Oak Knoll- 2-3 L, 10/28 vs Lenape- 1-0 W | |
| 19 | Sacred Heart Academy | Louisville, Kentucky | 25-3-0 | 19 | 10/25 vs Assumption- 1-0 W. KHSAA State Champions, Region 2 Champions. | |
| 20 | Twin Valley High School | Elverson, Pennsylvania | 21-2-0 | 20 | 10/27 vs Berks Catholic- 9-1 W, 10/30 vs Garden Spot- 5-0 W | |
| 21 | Assumption High School | Louisville, Kentucky | 21-6-2 | 21 | 10/25 vs Sacred Heart Academy- 0-1 L. KHSAA State Runner-Up, Region 3 Champions. | |
| 22 | Northport High School | Northport, New York | 18-0-0 | 23 | 10/28 vs Huntington- 6-0 W, 10/30 vs West Babylon- 5-0 W | |
| 23 | Wyoming Area High School | Exeter, Pennsylvania | 16-1-0 | 24 | None | |
| 24 | Garrison Forest School | Owings Mills, Maryland | 13-5-0 | NR | 10/25 @Good Counsel- 12-2 W, 10/28 vs St. Mary's- 6-0 W | |
| 25 | Walpole High School | Walpole, Massachusetts | 17-0-0 | 25 | 10/25 @Wellesley- 3-0 W, 10/29 vs Brookline- 4-0 W, 10/30 vs Braintree- 5-0 W | |
2021 HIGH SCHOOL WEEK #8
