| 1 | Emmaus High School | Emmaus, Pennsylvania | 21-0-0 | 1 | 10/19 vs Parkland- 2-0 W, 10/22 vs Easton- 2-1 W. EPC Champions | |
| 2 | Episcopal Academy | Newtown Square, Pennsylvania | 14-1-0 | 3 | 10/22 vs Archbishop Carroll- 6-0 W | |
| 3 | The Hill School | Pottstown, Pennsylvania | 13-1-0 | 4 | 10/20 vs Wyoming Seminary- 3-1 W, 10/23 vs Blair Academy- 9-0 W | |
| 4 | Lower Dauphin High School | Hummelstown, Pennsylvania | 17-0-1 | 6 | None | |
| 5 | Villa Maria Academy | Malvern, Pennsylvania | 14-2-1 | 2 | 10/19 @Academy of Notre Dame- 0-1 L, 10/21 vs Archbishop Carroll- 4-0 W | |
| 6 | Wyoming Seminary | Kingston, Pennsylvania | 15-2-0 | 5 | 10/18 vs Lackawanna Trail- 8-3 W, 10/20 vs The Hill School- 1-3 L | |
| 7 | Palmyra Area High School | Palmyra, Pennsylvania | 14-1-1 | 7 | None | |
| 8 | Conestoga High School | Berwyn, Pennsylvania | 17-1-0 | 8 | 10/18 @Haverford- 1-0 W, 10/19 vs Harriton- 7-0 W | |
| 9 | Gwynedd Mercy Academy High School | Gwynedd Valley, Pennsylvania | 12-2-1 | 9 | 10/19 @Unionville- 4-1 W | |
| 10 | Twin Valley High School | Elverson, Pennsylvania | 19-2-0 | 11 | 10/20 vs Wilson- 2-1 W, 10/23 @Oley Valley- 4-1 W | |
| 11 | Wyoming Area High School | Exeter, Pennsylvania | 15-1-0 | 12 | 10/18 vs Lake Lehman- 1-0 W, 10/21 vs Hazleton Area- 2-0 W | |
| 12 | Oley Valley High School | Oley, Pennsylvania | 18-2-0 | 10 | 10/18 vs Hamburg- 10-0 W, 10/20 vs Fleetwood- 4-1 W, 10/23 vs Twin Valley- 1-4 L | |
| 13 | Academy of Notre Dame de Namur | Villanova, Pennsylvania | 11-4-0 | 15 | 10/19 vs Villa Maria Academy- 1-0 W, 10/22 vs Agnes Irwin- 4-1 W | |
| 14 | Greenwood High School | Millerstown, Pennsylvania | 16-1-0 | 13 | 10/18 vs State College- 3-0 W | |
| 15 | Wilson High School | West Lawn, Pennsylvania | 16-4-0 | 14 | 10/18 vs Berks Catholic- 12-3 W, 10/20 @Twin Valley- 1-2 L | |
| 16 | Souderton Area High School | Souderton, Pennsylvania | 17-1-0 | 17 | 10/18 @Pennridge- 7-1 W, 10/20 vs CB West- 6-1 W, 10/21 @Harry S. Truman- 17-0 W | |
| 17 | Crestwood High School | Mountain Top, Pennsylvania | 16-2-0 | 18 | 10/18 vs Hazleton Area- 2-1 W, 10/19 vs Line Mountain- 9-0 W | |
| 18 | Mechanicsburg High School | Mechanicsburg, Pennsylvania | 12-5-0 | 16 | 10/20 @Hershey- 1-2 L | |
| 19 | Northern York High School | Dillsburg, Pennsylvania | 17-2-0 | 19 | 10/18 @Gettysburg- 8-0 W | |
| 20 | Upper Perkiomen High School | Pennsburg, Pennsylvania | 16-1-1 | OC | None | |
| | | | | | |
| OC | Cumberland Valley High School | Mechanicsburg, Pennsylvania | 14-3-0 | OC | 10/18 vs Mifflin County- 8-1 W, 10/20 vs Carlisle- 2-1 W | |
| OC | Downingtown West High School | Downingtown, Pennsylvania | 13-4-0 | OC | 10/18 vs WC Rustin- 10-2 W | |
| OC | Garnet Valley High School | Glen Mills, Pennsylvania | 14-3-0 | 20 | 10/19 @Haverford- 5-1 W, 10/20 vs Merion Mercy- 2-3 L | |
| OC | Great Valley High School | Malvern, Pennsylvania | 16-2-0 | OC | 10/19 vs Bishop Shanahan- 10-0 W, 10/21 vs Unionville- 4-0 W | |
| OC | Kennett High School | Kennett Square, Pennsylvania | 14-2-2 | OC | 10/19 @Coatesville- 1-0 W, 10/21 @Bishop Shanahan- 2-0 W | |
| OC | Merion Mercy Academy | Merion Station, Pennsylvania | 13-4-0 | NR | 10/19 @Lower Merion- 6-1 W, 10/20 @Garnet Valley- 3-2 W | |
| OC | Radnor High School | Radnor, Pennsylvania | 12-3-1 | OC | 10/19 vs Ridley- 8-0 W, 10/21 vs Strath Haven- 8-1 W | |
| OC | Southern Lehigh High School | Center Valley, Pennsylvania | 17-0-0 | OC | None | |
2021 PENNSYLVANIA REGION HIGH SCHOOL
