| 1 | Walpole High School | Walpole, Massachusetts | 9-0-0 | 1 | 10/6 vs Central Catholic- 4-1 W | |
| 2 | Phillips Academy Andover | Andover, Massachusetts | 7-0-0 | 2 | 10/6 @Governor's Academy- 3-0 W, 10/9 vs Choate- 10-0 W | |
| 3 | Masconomet Regional High School | Boxford, Massachusetts | 9-0-1 | 3 | 10/6 @Gloucester- 5-1 W, 10/7 @North Andover- 4-0 W, 10/9 @Danvers- 2-0 W | |
| 4 | Andover High School | Andover, Massachusetts | 9-0-1 | 4 | 10/4 vs Central Catholic- 3-1 W, 10/9 vs Shrewsbury- 6-0 W | |
| 5 | Watertown High School | Watertown, Massachusetts | 10-0-0 | 5 | 10/5 vs Belmont- 6-0 W, 10/7 @Woburn- 6-0 W, 10/9 @Winchester- 2-1 W | |
| 6 | Skowhegan Area High School | Skowhegan, Maine | 10-0-0 | 6 | 10/4 @Hampden Academy- 10-0 W, 10/6 @Edward Little- 5-0 W, 10/7 @Mt Blue- 3-1 W | |
| 7 | Longmeadow High School | Longmeadow, Massachusetts | 10-0-1 | 7 | 10/5 @Greenfield- 3-0 W, 10/7 vs Frontier Regional- 5-0 W | |
| 8 | Exeter High School | Exeter, New Hampshire | 14-0-0 | 9 | 10/4 @Bishop Guertin- 6-1 W, 10/7 vs Nashua North- 7-0 W | |
| 9 | Concord-Carlisle High School | Concord, Massachusetts | 9-0-1 | 12 | 10/4 vs Lincoln Sudbury- 5-0 W, 10/6 vs Chelmsford- 3-0 W, 10/8 vs Bedford- 2-0 W | |
| 10 | Cheverus High School | Portland, Maine | 11-0-0 | 10 | 10/4 vs Noble- 5-1 W, 10/6 @Gorham- 2-0 W, 10/8 vs South Portland- 11-0 W | |
| 11 | Sandwich High School | East Sandwich, Massachusetts | 9-0-1 | 14 | 10/4 vs Nantucket- 4-0 W, 10/6 vs Nauset- 2-0 W, 10/8 @Cohasset- 1-0 W | |
| 12 | Dover-Sherborn High School | Dover, Massachusetts | 6-1-0 | 15 | 10/4 vs Norwood- 2-0 W, 10/8 vs Ashland- 2-0 W | |
| 13 | Bedford High School | Bedford, New Hampshire | 13-1-0 | 11 | 10/4 @Manchester Memorial- 5-0 W, 10/6 vs Timberlane- 3-0 W | |
| 14 | Tabor Academy | Marion, Massachusetts | 6-2-0 | 8 | 10/6 @Noble & Greenough- 2-3 L, 10/9 vs Thayer- 3-0 W | |
| 15 | Franklin High School | Franklin, Massachusetts | 11-0-0 | 17 | 10/5 vs Stoughton- 10-0 W, 10/8 @King Philip- 2-0 W | |
| 16 | Brooks School | North Andover, Massachusetts | 5-1-1 | OC | 10/6 @Thayer- 2-1 W, 10/9 @Middlesex- 2-1 W | |
| 17 | Middlesex School | Concord, Massachusetts | 6-2-0 | 13 | 10/6 @Lawrence Academy- 4-0 W, 10/9 vs Brooks School- 1-2 L | |
| 18 | Wachusett Regional High School | Holden, Massachusetts | 9-0-4 | 18 | 10/6 @Shrewsbury- 3-1 W, 10/7 vs Notre Dame (Worcester)- 1-1 T, 10/8 vs Marlborough- 2-0 W | |
| 19 | Bellows Falls Union High School | Westminster, Vermont | 10-0-0 | 20 | 10/9 vs Otter Valley- 5-2 W | |
| 20 | Scarborough High School | Scarborough, Maine | 11-1-0 | OC | 10/4 vs Thornton Academy- 2-0 W, 10/6 @Noble- 1-0 W | |
| | | | | | |
| OC | Lexington High School | Lexington, Massachusetts | 6-1-2 | OC | 10/5 @Burlington- 2-2 T, 10/7 vs Wilmington- 1-0 W | |
| OC | Massabesic High School | Waterboro, Maine | 7-1-0 | 16 | 10/6 vs Biddeford- 0-2 L | |
| OC | Nashoba Regional High School | Bolton, Massachusetts | 8-2-1 | OC | 10/8 vs Algonquin- 7-1 W | |
| OC | Noble & Greenough School | Dedham, Massachusetts | 5-1-0 | NR | 10/6 vs Tabor- 3-2 W, 10/9 vs Exeter- 5-2 W | |
| OC | The Rivers School | Weston, Massachusetts | 5-1-1 | OC | 10/4 vs Dana Hall- 7-0 W, 10/9 vs Groton School- 3-0 W | |
| OC | Westwood High School | Westwood, Massachusetts | 7-0-1 | NR | 10/4 vs Medway- 4-2 W | |
| OC | Windham High School | Windham, New Hampshire | 11-2-1 | OC | 10/4 @Manchester Central-West- 2-0 W, 10/6 vs Concord- 0-2 L, 10/9 vs Merrimack- 5-0 W | |
| OC | Winsor School | Boston, Massachusetts | 5-0-0 | OC | 10/6 @Worcester Academy- 5-1 W | |
2021 NEW ENGLAND REGION HIGH SCHOOL
