| 1 | Walpole High School | Walpole, Massachusetts | 8-0-0 | 1 | 9/29 @Milton- 5-0 W, 10/2 @Cohasset- 4-0 W |
| 2 | Phillips Academy Andover | Andover, Massachusetts | 5-0-0 | 2 | 9/30 @Brooks School- 3-1 W, 10/2 @Tabor- 1-0 W |
| 3 | Masconomet Regional High School | Boxford, Massachusetts | 6-0-1 | 3 | 9/29 vs Swampscott- 4-0 W, 10/1 vs Saugus- 8-0 W |
| 4 | Andover High School | Andover, Massachusetts | 7-0-1 | 4 | 9/29 vs North Andover- 2-1 W, 10/1 vs Methuen- 6-0 W |
| 5 | Watertown High School | Watertown, Massachusetts | 7-0-0 | 5 | 9/29 @Wilmington- 7-0 W, 10/1 vs Stoneham- 6-0 W |
| 6 | Skowhegan Area High School | Skowhegan, Maine | 7-0-0 | 6 | 9/30 vs Nokomis Regional- 1-0 W, 10/1 @Brunswick- 5-0 W |
| 7 | Longmeadow High School | Longmeadow, Massachusetts | 8-0-1 | 8 | 10/1 vs Hall (CT)- 1-1 T |
| 8 | Tabor Academy | Marion, Massachusetts | 5-1-0 | 10 | 9/29 @Middlesex- 2-1 W, 10/2 vs Phillips Academy Andover- 0-1 L |
| 9 | Exeter High School | Exeter, New Hampshire | 12-0-0 | 11 | 10/1 vs Concord- 4-0 W |
| 10 | Cheverus High School | Portland, Maine | 8-0-0 | 13 | 9/28 vs Windham- 5-0 W, 9/30 @Thornton Academy- 4-0 W |
| 11 | Bedford High School | Bedford, New Hampshire | 11-1-0 | 14 | 9/29 @Nashua North- 9-0 W |
| 12 | Concord-Carlisle High School | Concord, Massachusetts | 6-0-1 | 15 | 9/30 vs Weston- 6-0 W |
| 13 | Middlesex School | Concord, Massachusetts | 5-1-0 | 17 | 9/29 vs Tabor Academy- 1-2 L, 10/2 vs Milton Academy- 4-0 W |
| 14 | Sandwich High School | East Sandwich, Massachusetts | 6-0-1 | 9 | 9/29 @Falmouth- 0-0 T, 10/1 @Monomoy- 3-0 W |
| 15 | Dover-Sherborn High School | Dover, Massachusetts | 4-1-0 | 7 | 9/29 vs Medfield- 0-1 L |
| 16 | Massabesic High School | Waterboro, Maine | 7-0-0 | 19 | 9/28 @Marshwood- 5-2 W |
| 17 | Franklin High School | Franklin, Massachusetts | 9-0-0 | NR | 9/29 @Foxborough- 6-1 W, 10/1 @Milford- 8-0 W |
| 18 | Wachusett Regional High School | Holden, Massachusetts | 7-0-3 | 18 | 9/29 @Nashoba Regional- 2-1 W, 10/1 @Tantasqua- 4-0 W |
| 19 | Deerfield Academy | Deerfield, Massachusetts | 4-1-0 | OC | 9/29 @Milton Academy- 2-0 W, 10/2 vs Exeter- 4-2 W |
| 20 | Bellows Falls Union High School | Westminster, Vermont | 9-0-0 | OC | 10/1 vs Rutland- 8-0 W |
| | | | | |
| OC | Acton-Boxborough Regional High School | Acton, Massachusetts | 6-1-1 | 16 | 9/30 @Bedford- 5-0 W |
| OC | Brooks School | North Andover, Massachusetts | 3-1-1 | OC | 9/29 vs St. Mark's- 2-1 W, 10/2 @Groton- 2-1 W |
| OC | Chelmsford High School | North Chelmsford, Massachusetts | 4-1-1 | OC | 9/29 vs Central Catholic- 2-1 W |
| OC | Cushing Academy | Ashburnham, Massachusetts | 4-1-0 | OC | 9/29 vs Lawrence Academy- 4-0 W, 10/2 vs Brewster Academy- 2-0 W |
| OC | Lexington High School | Lexington, Massachusetts | 5-1-1 | OC | 9/29 vs Reading- 2-1 W |
| OC | Nashoba Regional High School | Bolton, Massachusetts | 7-2-1 | 20 | 9/29 vs Wachusett Regional- 1-2 L |
| OC | Scarborough High School | Scarborough, Maine | 9-1-0 | OC | 9/28 vs Westbrook- 8-0 W, 9/30 @Windham- 4-0 W |
| OC | The Rivers School | Weston, Massachusetts | 3-1-1 | 12 | 9/29 vs St. Paul's School- 2-0 W, 10/2 vs The Governor's Academy- 1-1 T |
| OC | Windham High School | Windham, New Hampshire | 9-1-1 | OC | 9/29 vs Winnacunnet- 3-1 W, 10/1 @Pinkerton- 4-0 W, 10/2 @Salem- 3-1 W |
| OC | Winsor School | Boston, Massachusetts | 4-0-0 | OC | 10/2 vs New Hampton School- 2-1 W |
2021 NEW ENGLAND REGION HIGH SCHOOL
