| 1 | Walpole High School | Walpole, Massachusetts | 0-0-0 | 1 | 9/9 vs Natick- Postponed |
| 2 | Acton-Boxborough Regional High School | Acton, Massachusetts | 1-0-0 | 4 | 9/11 vs Westford Academy- 6-0 W |
| 3 | Phillips Academy Andover | Andover, Massachusetts | 0-0-0 | 7 | None |
| 4 | Masconomet Regional High School | Boxford, Massachusetts | 2-0-0 | 6 | 9/8 @Saugus- 9-0 W, 9/10 vs Peabody- 10-1 W |
| 5 | Andover High School | Andover, Massachusetts | 1-0-0 | 8 | 9/11 vs Cohasset- 5-0 W |
| 6 | The Rivers School | Weston, Massachusetts | 0-0-0 | 5 | None |
| 7 | Watertown High School | Watertown, Massachusetts | 0-0-0 | 9 | None |
| 8 | Skowhegan Area High School | Skowhegan, Maine | 2-0-0 | 10 | 9/2 @Bangor- 10-0 W, 9/7 vs Mt. Ararat- 6-0 W |
| 9 | Nashoba Regional High School | Bolton, Massachusetts | 2-0-0 | 3 | 9/8 vs Shrewsbury- 3-2 W, 9/11 vs North Middlesex- 7-0 W |
| 10 | Dover-Sherborn High School | Dover, Massachusetts | 0-0-0 | 11 | None |
| 11 | Windham High School | Windham, New Hampshire | 3-0-1 | 12 | 8/27 @Bishop Guertin- 1-1 T, 8/30 vs Nashua North- 7-0 W, 9/3 vs Dover- 1-0 W, 9/7 @Timberlane- 2-0 W |
| 12 | Longmeadow High School | Longmeadow, Massachusetts | 3-0-0 | 13 | 9/8 vs Greenfield- 4-0 W, 9/10 @Frontier- 3-1 W, 9/11 vs Cicero North Syracuse (NY)- 2-1 W |
| 13 | Pingree School | South Hamilton, Massachusetts | 0-0-0 | 14 | None |
| 14 | Brooks School | North Andover, Massachusetts | 0-0-0 | 15 | None |
| 15 | Sandwich High School | East Sandwich, Massachusetts | 1-0-0 | 16 | 9/8 @Plymouth North- 7-1 W |
| 16 | Lexington High School | Lexington, Massachusetts | 1-0-0 | 18 | 9/10 vs Stoneham- 7-0 W |
| 17 | Tabor Academy | Marion, Massachusetts | 0-0-0 | 19 | None |
| 18 | Exeter High School | Exeter, New Hampshire | 6-0-0 | OC | 8/27 @Salem- 5-1 W, 8/30 vs Dover- 3-0 W, 9/1 @Timberlane- 4-0 W, 9/3 @Merrimack- 8-0 W, 9/10 vs Manchester Memorial- 5-2 W, 9/11 @Bedford- 2-1 WÂ |
| 19 | The Governor's Academy | Byfield, Massachusetts | 0-0-0 | 20 | None |
| 20 | Scarborough High School | Scarborough, Maine | 3-0-0 | NR | 9/2 vs Falmouth- 2-0 W, 9/4 @Portland/Deering- 8-0 W, 9/11 @Biddeford- 2-0 W |
| | | | | |
| OC | Bellows Falls Union High School | Westminster, Vermont | 3-0-0 | OC | 9/3 @Springfield- 12-0 W, 9/8 vs Windsor- 8-0 W, 9/11 @Rutland- 8-0 W |
| OC | Belmont High School | Belmont, Massachusetts | 1-0-0 | NR | 9/9 vs Wilmington- 3-2 W |
| OC | Bishop Guertin High School | Nashua, New Hampshire | 4-0-1 | OC | 8/27 vs Windham- 1-1 T, 8/30 @Pinkerton- 4-2 W, 9/1 vs Manchester Central-West- 2-0 W, 9/3 @Concord- 2-0 W, 9/8 @Nashau North- 7-1 W |
| OC | Chelmsford High School | North Chelmsford, Massachusetts | 0-0-1 | OC | 9/10 vs Wachusett- 1-1 T |
| OC | Cheverus High School | Portland, Maine | 3-0-0 | NR | 9/1 vs Marshwood- 8-0 W, 9/8 vs Biddeford- 6-2 W, 9/10 @Sanford- 8-0 W |
| OC | Deerfield Academy | Deerfield, Massachusetts | 0-0-0 | OC | None |
| OC | Middlesex School | Concord, Massachusetts | 0-0-0 | OC | None |
| OC | Wachusett Regional High School | Holden, Massachusetts | 0-0-2 | NR | 9/8 vs Algonquin- 1-1 T, 9/10 @Chelmsford- 1-1 T |
2021 NEW ENGLAND REGION HIGH SCHOOL
