| 1 | Kinkaid School | Houston, Texas | 11-1-0 | 1 | 10/12 vs Awty Intl- 11-0 W, 10/14 vs Episcopal- W | |
| 2 | Sacred Heart Academy | Louisville, Kentucky | 20-3-0 | 2 | 10/12 vs KCD- 3-1 W, 10/18 vs Eastern- 9-0 W | |
| 3 | Assumption High School | Louisville, Kentucky | 17-5-2 | 3 | 10/14 @MICDS- 3-2 W | |
| 4 | Ann Arbor Pioneer High School | Pioneer, Michigan | 19-0-0 | 4 | 10/11 @Novi- 5-0 W, 10/15 vs Marian- 8-0 W | |
| 5 | St. John's School | Houston, Texas | 10-2-0 | 6 | 10/15 @St Stephen's- 3-0 W, 10/16 @St. Andrews- 9-0 W | |
| 6 | Villa Duchesne & Oak Hill School | Frontenac, Missouri | 16-2-2 | 5 | 10/14 vs Cor Jesu- 0-1 L | |
| 7 | New Trier High School | Winnetka, Illinois | 18-6-1 | 8 | 10/12 vs Glenbrook South- 6-1 W, 10/14 vs Lake Forest- 1-1 T | |
| 8 | Lake Forest High School | Lake Forest, Illinois | 17-3-1 | 9 | 10/14 @New Trier- 1-1 T | |
| 9 | Canyon Hills High School | Sain Diego, California | 14-2-0 | 10 | 10/12 vs Scripps Ranch- 4-0 W | |
| 10 | Bishop Watterson High School | Columbus, Ohio | 15-0-1 | 13 | 10/11 vs Bishop Hartley- 6-0 W | |
| 11 | Scripps Ranch High School | San Diego, California | 11-1-1 | 7 | 10/12 @Canyon Hills- 0-4 L | |
| 12 | Ballard High School | Louisville, Kentucky | 14-7-0 | 12 | 10/11 vs South Oldham- 1-0 W, 10/14 vs Eastern- 5-0 W | |
| 13 | Skyline High School | Ann Arbor, Michigan | 11-2-1 | 14 | 10/11 vs Huron- 8-0 W, 10/12 @Dexter- 5-3 W | |
| 14 | Thomas Worthington High School | Worthington, Ohio | 12-2-1 | 11 | 10/13 vs Upper Arlington- 0-1 L OT | |
| 15 | New Albany High School | New Albany, Ohio | 10-2-1 | 16 | 10/11 vs Upper Arlington- 1-0 W, 10/13 vs Dublin Jerome- 4-0 W | |
| 16 | Saline High School | Saline, Michigan | 9-3-1 | 18 | 10/13 vs Chelsea- 3-0 W | |
| 17 | Torrey Pines High School | San Diego, California | 14-3-0 | 19 | 10/13 vs RBV- 3-0 W, 10/15 @San Pasqual- 3-0 W | |
| 18 | Archbishop Mitty High School | San Jose, California | 7-3-3 | 20 | 10/12 vs Saint Francis- 0-0 T OT, 10/14 @Los Altos- 1-0 W | |
| 19 | Glenbrook South High School | Glenview, Illinois | 16-3-0 | 15 | 10/12 @New Trier- 1-6 L, 10/13 vs Francis W Parker- 4-1 W, 10/14 vs NSCD- 6-1 W | |
| 20 | MICDS | Saint Louis, Missouri | 12-4-0 | OC | 10/12 @Ladue- 3-0 W, 10/14 vs Assumption (KY)- 2-3 L | |
| | | | | | |
| OC | Bonita High School | La Verne, California | 10-1-0 | NR | 10/12 vs Harvard Westlake- 2-1 W, 10/14 vs Chaminade- 6-1 W | |
| OC | Canyon Crest Academy | San Diego, California | 13-5-0 | OC | 10/13 @San Pasqual- 4-0 W, 10/15 vs Mission Vista- 2-0 W | |
| OC | Christopher High School | Gilroy, California | 11-1-2 | OC | 10/11 vs North Salinas- 10-0 W, 10/14 vs Gilroy- 1-1 T OT | |
| OC | Columbus Academy | Columbus, Ohio | 12-4-1 | OC | 10/13 @Granville- 2-0 W, 10/14 vs Worthington Kilbourne- 1-0 W | |
| OC | Harvard-Westlake School | Los Angeles, California | 10-2-0 | 17 | 10/12 @Bonita- 1-2 L | |
| OC | Los Gatos High School | Los Gatos, California | 9-1-0 | OC | 10/12 @Presentation- 10-0 W, 10/14 @St. Ignatius- 5-0 W | |
| OC | Oak Park & River Forest High School | Oak Park, Illinois | 15-5-1 | OC | 10/13 @Glenbard West- W | |
| OC | Olentangy Liberty High School | Powell, Ohio | 12-3-1 | OC | 10/13 vs Dublin Scioto- 2-1 W, 10/14 vs Dublin Coffman- 6-0 W | |
| OC | Saint Francis High School | Mountain View, California | 11-1-1 | OC | 10/12 @Archbishop Mitty- 0-0 T, 10/13 @Los Altos- 1-0 W, 10/14 vs Presentation- 3-0 W | |
| OC | Upper Arlington High School | Columbus, Ohio | 12-3-1 | NR | 10/11 @New Albany- 0-1 L, 10/13 vs Thomas Worthington- 1-0 W OT | |
2021 WEST/MID-WEST REGION HIGH SCHOOL
