| 1 | Watertown High School | Watertown, Massachusetts | 22-0-0 | Division 3 State Champions |
| 2 | Andover High School | Andover, Massachusetts | 22-1-0 | Division I State Champions |
| 3 | Skowhegan Area High School | Skowhegan, Maine | 18-0-0 | Class A State Champions |
| 4 | Longmeadow High School | Longmeadow, Massachusetts | 17-1-2 | Division 2 State Champions |
| 5 | Cheverus High School | Portland, Maine | 17-1-0 | Class A State Finalist |
| 6 | Walpole High School | Walpole, Massachusetts | 21-2-0 | Division I State Finalist |
| 7 | Masconomet Regional High School | Boxford, Massachusetts | 18-1-2 | Division 2 State Semifinalist |
| 8 | Exeter High School | Exeter, New Hampshire | 17-1-1 | New Hampshire Division I State Champions |
| 9 | The Governor's Academy | Byfield, Massachusetts | 17-4-0 | NEPSAC B Champions |
| 10 | Phillips Academy Andover | Andover, Massachusetts | 15-2-1 | NEPSAC A Semifinalist |
| 11 | Shrewsbury High School | Shrewsbury, Massachusetts | 18-3-0 | Division 1 State Semifinalist |
| 12 | Uxbridge High School | Uxbridge, Massachusetts | 18-0-0 | Division 4 State Champions |
| 13 | Winnacunnet High School | Hampton, New Hampshire | 15-2-1 | New Hampshire Division I State Finalist |
| 14 | Middlesex School | Concord, Massachusetts | 14-4-1 | NEPSAC B Finalist |
| 15 | Noble & Greenough School | Dedham, Massachusetts | 14-3-1 | NEPSAC A Semifinalist |
| 16 | Pingree School | South Hamilton, Massachusetts | 21-2-1 | NEPSAC C Champions |
| 17 | Sandwich High School | East Sandwich, Massachusetts | 19-1-1 | Division 3 State Finalist |
| 18 | Tabor Academy | Marion, Massachusetts | 16-3-0 | NEPSAC A First Round |
| 19 | Champlain Valley Union High School | Hinesburg, Vermont | 15-2-0 | Division 1 State Champions |
| 20 | South Burlington High School | South Burlington, Vermont | 13-3-1 | Division I State Finalist |
| | | | |
| OC | Dover High School | Dover, New Hampshire | 14-4-0 | New Hampshire Division I State Semifinalist |
| OC | Dover-Sherborn High School | Dover, Massachusetts | 16-2-4 | Division 3 State Semifinalist |
| OC | Oxford Hills High School | South Paris, Maine | 13-4-1 | Maine Class A State Semifinalist |
| OC | Wachusett Regional High School | Holden, Massachusetts | 14-4-1 | Division I State Semifinalist |
| OC | Windham High School | Windham, New Hampshire | 14-3-1 | New Hampshire Division I State Semifinalist |
2022 NEW ENGLAND REGION HIGH SCHOOL
