| 1 | Emmaus High School | Emmaus, Pennsylvania | 12-0-0 | 1 | 9/28 vs William Allen- 10-0 W, 9/30 vs Pleasant Valley- 13-0 W, 10/2 @Stroudsburg- 8-0 W | |
| 2 | Villa Maria Academy | Malvern, Pennsylvania | 10-1-0 | 2 | 9/29 vs Mount Saint Joseph- 7-1 W, 9/30 vs Merion Mercy- 5-2 W | |
| 3 | Episcopal Academy | Newtown Square, Pennsylvania | 9-1-0 | 3 | 9/30 vs Springside Chestnut Hill Academy- 8-0 W, 10/2 vs Wyoming Seminary- 2-1 W | |
| 4 | The Hill School | Pottstown, Pennsylvania | 7-1-0 | 5 | 10/1 vs West Essex (NJ)- 4-0 W | |
| 5 | Lower Dauphin High School | Hummelstown, Pennsylvania | 11-0-1 | 4 | 9/28 @Palmya Area- 1-1 T, 9/30 vs Hershey- 2-1 W | |
| 6 | Wyoming Seminary | Kingston, Pennsylvania | 7-1-0 | 6 | 9/29 @Honesdale- 6-1 W, 10/2 @The Hill School- 1-2 L | |
| 7 | Palmyra Area High School | Palmyra, Pennsylvania | 10-1-1 | 7 | 9/28 vs Lower Dauphin- 1-1 T, 9/30 vs Mechanicsburg- 6-1 W | |
| 8 | Oley Valley High School | Oley, Pennsylvania | 12-0-0 | 8 | 9/30 vs Brandywine Heights- 13-0 W, 10/2 vs Berks Catholic- 6-1 W | |
| 9 | Conestoga High School | Berwyn, Pennsylvania | 9-1-0 | 10 | 9/28 vs Ridley- 8-0 W, 9/30 @Garnet Valley- 3-2 W, 10/2 @Mount Saint Joseph- 8-0 W | |
| 10 | Twin Valley High School | Elverson, Pennsylvania | 10-1-0 | 9 | 9/29 vs Wilson- 2-1 W | |
| 11 | Wyoming Area High School | Exeter, Pennsylvania | 8-1-0 | 11 | 9/29 @Lackawanna Trail- 3-0 W, 10/1 vs Lewisburg- 3-0 W | |
| 12 | Greenwood High School | Millerstown, Pennsylvania | 8-0-0 | 12 | 9/28 vs Susquenita- 6-2 W, 9/30 @Line Mountain- 3-0 W | |
| 13 | Gwynedd Mercy Academy High School | Gwynedd Valley, Pennsylvania | 8-2-0 | 14 | 9/30 vs Villa Joseph Marie- 11-1 W, 10/1 @Germantown Academy- 10-1 W | |
| 14 | Garnet Valley High School | Glen Mills, Pennsylvania | 9-1-0 | 13 | 9/30 vs Conestoga- 2-3 L, 10/1 @Cardinal O'Hara- 3-0 W | |
| 15 | Academy of Notre Dame de Namur | Villanova, Pennsylvania | 7-2-0 | 18 | 9/28 @Agnes Irwin- 4-1 W, 10/1 @William Penn Charter- 4-0 W | |
| 16 | Wilson High School | West Lawn, Pennsylvania | 8-3-0 | 16 | 9/29 @Twin Valley- 1-2 L, 10/2 @Downingtown East- 3-2 W | |
| 17 | Great Valley High School | Malvern, Pennsylvania | 8-1-0 | OC | 9/30 vs WC Rustin- 6-0 W | |
| 18 | Mechanicsburg High School | Mechanicsburg, Pennsylvania | 8-4-0 | 15 | 9/28 vs East Pennsboro- 5-4 W, 9/30 @Palmyra Area- 1-6 L | |
| 19 | Nazareth Area High School | Nazareth, Pennsylvania | 12-0-0 | NR | 9/28 @Parkland- 2-1 W, 9/30 vs Pocono Mountain East- 1-0 W, 10/2 @Lehighton- 2-1 W | |
| 20 | Southern Lehigh High School | Center Valley, Pennsylvania | 12-0-0 | NR | 9/29 vs Saucon Valley- 2-0 W, 10/1 vs Northern Lehigh- 6-0 W, 10/2 @Parkland- 1-0 W | |
| | | | | | |
| OC | Crestwood High School | Mountain Top, Pennsylvania | 9-2-0 | OC | 9/29 @Dallas- 3-0 W, 10/2 vs Wallenpaupack- 5-0 W | |
| OC | Cumberland Valley High School | Mechanicsburg, Pennsylvania | 9-2-0 | OC | 9/28 vs Cedar Cliff- 6-1 W, 9/30 @Central Dauphin- 2-1 W, 10/2 vs West Perry- 3-0 W, 10/2 vs Penn Manor- 0-1 L | |
| OC | Kennett High School | Kennett Square, Pennsylvania | 8-1-1 | OC | 9/28 @WC East- 2-2 T, 9/30 @WC Henderson- 2-1 W | |
| OC | Northern York High School | Dillsburg, Pennsylvania | 9-0-0 | NR | 9/28 @West Perry- 2-0 W, 10/2 vs Greencastle Antrim- 5-1 W | |
| OC | Penn Manor High School | Millersville, Pennsylvania | 13-2-0 | 19 | 9/29 @Manheim Twp- 2-0 W, 10/1 vs Conestoga Valley- 0-1 L, 10/2 vs Exeter Twp- 6-0 W, 10/2 @Cumberland Valley- 1-0 W | |
| OC | Souderton Area High School | Souderton, Pennsylvania | 8-1-0 | OC | 9/30 @Pennsbury- 7-0 W | |
2021 PENNSYLVANIA REGION HIGH SCHOOL
