| 1 | Episcopal Academy | Newtown Square, Pennsylvania | 5-0-0 | 1 | 9/14 vs Lawrenceville School- 11-0 W, 9/15 vs Villa Maria Academy- 4-2 W, 9/17 @ The Hill School- 3-0 W | |
| 2 | Emmaus High School | Emmaus, Pennsylvania | 5-0-0 | 2 | 9/16 @Easton Area- 3-1 W, 9/18 vs Northampton- 9-0 W | |
| 3 | Lower Dauphin High School | Hummelstown, Pennsylvania | 8-0-0 | 5 | 9/14 @Hershey- 2-0 W, 9/16 vs Red Land- 3-0 W, 9/18 vs Twin Valley- 2-0 W | |
| 4 | The Hill School | Pottstown, Pennsylvania | 4-1-0 | 3 | 9/15 vs Academy of Notre Dame- 2-1 W, 9/17 vs Episcopal Academy- 0-3 L | |
| 5 | Wyoming Seminary | Kingston, Pennsylvania | 2-0-0 | 4 | 9/13 @Hazleton Area- 8-0 W, 9/15 vs Crestwood- 1-0 W | |
| 6 | Palmyra Area High School | Palmyra, Pennsylvania | 4-1-0 | 6 | 9/14 @Mechanicsburg- 1-0 W, 9/16 vs East Pennsboro- 1-0 W, 9/18 vs Central York- 8-0 W | |
| 7 | Wyoming Area High School | Exeter, Pennsylvania | 3-0-0 | 7 | 9/13 @Holy Redeemer- 6-1 W, 9/18 vs Line Mountain- 1-0 W | |
| 8 | Oley Valley High School | Oley, Pennsylvania | 5-0-0 | 9 | 9/13 @Spring-Ford- 2-0 W, 9/15 vs Schuylkill Valley- 6-0 W | |
| 9 | Twin Valley High School | Elverson, Pennsylvania | 5-1-0 | 8 | 9/13 @Governor Mifflin- 9-1 W, 9/15 vs Reading- 9-0 W, 9/18 @Lower Dauphin- 0-2 L | |
| 10 | Conestoga High School | Berwyn, Pennsylvania | 4-0-0 | 11 | 9/14 @Marple Newtown- 6-0 W | |
| 11 | Villa Maria Academy | Malvern, Pennsylvania | 4-1-0 | 12 | 9/13 @ Merion Mercy- 6-0 W, 9/15 @ Episcopal Academy- 2-4 L, 9/17 vs Gwynedd Mercy Academy- 3-2 W | |
| 12 | Greenwood High School | Millerstown, Pennsylvania | 6-0-0 | 13 | 9/14 vs Line Mountain- 4-0 W, 9/16 vs East Juniata- 11-0 W | |
| 13 | Penn Manor High School | Millersville, Pennsylvania | 8-0-0 | 15 | 9/13 vs Cedar Crest- 5-1 W, 9/15 vs Manheim Twp- 2-0 W, 9/17 vs Conestoga Valley- 1-0 W | |
| 14 | Garnet Valley High School | Glen Mills, Pennsylvania | 6-0-0 | 19 | 9/14 @Springfield- 8-0 W, 9/17 vs Downingtown West- 2-0 W | |
| 15 | Gwynedd Mercy Academy High School | Gwynedd Valley, Pennsylvania | 4-2-0 | 14 | 9/15 vs Mount Saint Joseph- 8-0 W, 9/17 @Villa Maria- 2-3 L, 9/18 vs Radnor- 2-1 W | |
| 16 | Mechanicsburg High School | Mechanicsburg, Pennsylvania | 4-2-0 | 20 | 9/13 @West Perry- 4-2 W, 9/14 vs Palmyra- 0-1 L | |
| 17 | Selinsgrove Area High School | Selinsgrove, Pennsylvania | 5-1-0 | 18 | 9/14 vs Southern Columbia- 8-0 W, 9/16 vs Danville Area- 4-0 W, 9/18 vs Wyoming Area- 2-3 L, 9/18 vs Line Mountain- 1-0 W | |
| 18 | Hershey High School | Hershey, Pennsylvania | 4-3-0 | OC | 9/14 vs Lower Dauphin- 0-2 L, 9/18 @Wilson- 3-2 W | |
| 19 | Wilson High School | West Lawn, Pennsylvania | 4-2-0 | 10 | 9/13 @Exeter- 7-0 W, 9/15 vs Governor Mifflin- 6-0 W, 9/18 vs Hershey- 2-3 L | |
| 20 | Parkland High School | Allentown, Pennsylvania | 7-0-0 | OC | 9/14 vs Stroudsburg- 3-2 W, 9/16 @William Allen- 10-0 W, 9/18 vs Pleasant Valley- 3-0 W | |
| | | | | | |
| OC | Academy of Notre Dame de Namur | Villanova, Pennsylvania | 2-2-0 | OC | 9/13 vs Mount Saint Joseph's- 5-1 W, 9/15 @Hill School- 1-2 L, 9/17 vs Archbishop Carroll- 1-3 L | |
| OC | Archbishop Carroll High School | Radnor, Pennsylvania | 5-2-0 | NR | 9/14 vs Agnes Irwin- 4-3 W, 9/15 vs St. Hubert's- 14-0 W, 9/17 vs Academy of Notre Dame- 3-1 W | |
| OC | Berks Catholic High School | Reading, Pennsylvania | 4-0-0 | NR | 9/13 vs Daniel Boone- 8-2 W, 9/16 vs Exeter Twp- 9-2 W | |
| OC | Crestwood High School | Mountain Top, Pennsylvania | 5-1-0 | NR | 9/13 vs Wyoming Valley West- 2-0 W, 9/15 @Wyoming Sem- 0-1 L | |
| OC | Cumberland Valley High School | Mechanicsburg, Pennsylvania | 3-1-0 | NR | 9/14 vs Central Dauphin- 4-2 W, 9/16 vs State College Area- 1-2 L | |
| OC | Downingtown West High School | Downingtown, Pennsylvania | 3-2-0 | OC | 9/13 vs Oxford- 6-0 W, 9/15 @Coatesville- 1-0 W, 9/17 @Garnet Valley- 0-2 L | |
| OC | Easton Area High School | Easton, Pennsylania | 3-2-0 | NR | 9/16 vs Emmaus- 1-3 L, 9/17 vs Warren Hills (NJ)- 5-0 W | |
| OC | East Pennsboro High School | Enola, Pennsylvania | 2-3-2 | NR | 9/14 @Red Land- 3-1 W, 9/16 @Palmyra- 0-1 L, 9/18 vs Susquehannock- 5-1 W | |
| OC | Kennett High School | Kennett Square, Pennsylvania | 5-0-0 | OC | 9/13 vs Downingtown East- 2-1 W, 9/15 @Sun Valley- 9-0 W | |
| OC | Souderton Area High School | Souderton, Pennsylvania | 4-1-0 | OC | 9/14 vs CB East- 3-1 W, 9/17 @North Penn- 4-3 W | |
| OC | State College Area High School | State College, Pennsylvania | 4-0-0 | NR | 9/13 vs Chambersburg Area- 5-0 W, 9/16 vs Cumberland Valley- 2-1 W | |
2021 PENNSYLVANIA REGION HIGH SCHOOL
